Just to clarify, are you looking for a two-hander (one man and one woman) or a solo piece?
If the former, my suggestion is admittedly basic -- all the scenes in Almost, Maine are two-character scenes, and they range from hilarious to heartbreaking.
I also second the suggestion of I and You, which is a beautiful play.
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Cassy Maxton-Whitacre
Theatre, Film, and Communications Instructor
Shenandoah Valley Governor's School
Fishersville, VA
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